Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis

P Dahal; JA Simpson; S Abdulla; J Achan; I Adam; A Agarwal; R Allan; AR Anvikar; E Arinaitwe; EA Ashley; GR Awab; Q Bassat; A Björkman; S Borrmann; T Bousema; H Bukirwa; VI Carrara; M Corsi; M Cot; U D’Alessandro; TME Davis; P Deloron; M Desai; PR Dimbu; D Djalle; A Djimde; G Dorsey; CJ Drakeley; S Duparc; MD Edstein; E Espie; A Faiz; C Falade; C Fanello; JF Faucher; B Faye; F de Jesus Fortes; NB Gadalla; O Gaye; JP Gil; J Gilayeneh; B Greenwood; A Grivoyannis; TT Hien; J Hwang; B Janssens; E Juma; E Kamugisha; C Karema; HA Karunajeewa; JR Kiechel; F Kironde; PE Kofoed; PG Kremsner; SJ Lee; K Marsh; A Mårtensson; M Mayxay; H Menan; P Mens; TK Mutabingwa; JL Ndiaye; BE Ngasala; H Noedl; F Nosten; AT Offianan; BR Ogutu; PL Olliaro; JB Ouedraogo; P Piola; CV Plowe; MM Plucinski; OJ Pratt; Z Premji; M Ramharter; C Rogier; L Rombo; PJ Rosenthal; C Sibley; S Sirima; F Smithuis; SG Staedke; I Sutanto; AO Talisuna; J Tarning; WRJ Taylor; E Temu; K Thriemer; N Thuy-Nhien; V Udhayakumar; J Ursing; M van Herp; M van Lenthe; M van Vugt; Y William; C Winnips; S Zaloumis; I Zongo; NJ White; PJ Guerin

Journal article

Temporal distribution of Plasmodium falciparum recrudescence following artemisinin-based combination therapy: an individual participant data meta-analysis

P Dahal, JA Simpson, S Abdulla, J Achan, I Adam, A Agarwal, R Allan, AR Anvikar, E Arinaitwe, EA Ashley, GR Awab, Q Bassat, A Björkman, S Borrmann, T Bousema, H Bukirwa, VI Carrara, M Corsi, M Cot, U D’Alessandro Show all

Malaria Journal | Published : 2022

DOI: 10.1186/s12936-021-03980-z

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Abstract

Background: The duration of trial follow-up affects the ability to detect recrudescent infections following anti-malarial treatment. The aim of this study was to explore the proportions of recrudescent parasitaemia as ascribed by genotyping captured at various follow-up time-points in treatment efficacy trials for uncomplicated Plasmodium falciparum malaria. Methods: Individual patient data from 83 anti-malarial efficacy studies collated in the WorldWide Antimalarial Resistance Network (WWARN) repository with at least 28 days follow-up were available. The temporal and cumulative distributions of recrudescence were characterized using a Cox regression model with shared frailty on study-sites...

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University of Melbourne Researchers

Julie Simpson Author

Sophie Zaloumis Author

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INTEGRATION OF BIOSTATISTICS AND MATHEMATICAL MODELLING TO IMPROVE THE CONTROL OF INFECTIOUS DISEASES

Improving the control of infectious diseases requires the evaluation of interventions that prevent disease at the population level and succe..

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Awarded by Bill and Melinda Gates Foundation

Funding Acknowledgements

This work was funded by Tropical Network Fund, Nuffield Department of Clinical Medicine, University of Oxford to PD. The WorldWide Antimalarial Resistance Network (PD, KS, RNP and PJG) is funded by a Bill and Melinda Gates Foundation grant. JAS is an Australian National Health and Medical Research Council Senior Research Fellow (1104975). RNP is a Wellcome Trust Senior Fellow in Clinical Science (200909). The funders did not participate in the study development, the writing of the paper, decision to publish, or preparation of the manuscript.